Antibody Glycosylation Predicts Relapse in Autoimmune Vasculitis
نویسنده
چکیده
Article history: Received 9 February 2017 Accepted 9 February 2017 Available online 10 February 2017 non-relapsing patients the glycosylation profiles did not change. Somewhat surprising, PR3-ANCA galactosylation, sialylation, and fucosylation decreased in both relapsing and non-relapsing patients. It has been known for some30years now thatmanifest autoimmune disease is correlated with changes in the glycosylation of antibodies (Parekh et al., 1985), and the list of autoimmune diseases with alter-
منابع مشابه
Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis
OBJECTIVE The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS Seventy-five patients with GPA and a PR3-ANCA rise during follow-up were included, of whom 43 patients relapsed within a median ...
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2017